B1k Assassin, I got the same problem too. luckily I found the solution from one of the threads here. The solution is to have an empty SilkRoad folder under C:\Program Files\. It just got it working in the last 15 minutes.
I wonder why this is causes the problem. One thing for sure is that I have Norton Internet Security that comes with my laptop and it seems to prevent the setup to one thing or another. Hopefully, the game runs well after install, otherwise i will just uninstall the norton.
Have fun.